A comparison of A-level performance in economics and business studies: how much more difficult is economics?

This paper uses ALIS data to compare academic performance in two subjects often viewed as relatively close substitutes for one another at A-level. The important role of GCSE achievement is confirmed for both subjects. There is evidence of strong gender effects and variation in outcomes across Examination Boards. A counterfactual exercise suggests that if the sample of Business Studies candidates had studied Economics nearly 40% of those who obtained a grade C or better in the former subject would not have done so in the latter. The opposite exercise uggests that 12% more Economics candidates would have achieved a grade C or better if they had taken Business Studies. In order to render a Business Studies A-level grade comparable to an Economics one in terms of relative difficulty, we estimate that a downward adjustment of 1.5 UCAS points should be applied to the former subject. This adjustment is lower than that suggested by correction factors based on conventional subject pair analysis for these two subjects

Prostate-specific antigen testing in inner London general practices: are those at higher risk most likely to get tested?

This study was funded by the Guy’s and St Thomas’ Hospital Charity (Fund 201)

High Ratio of 44Ti/56Ni in Cas A and Axisymmetric Collapse-Driven Supernova Explosion

The large abundance ratio of $^{44}Ti/^{56}Ni$ in Cas A is puzzling. In fact, the ratio seems to be larger than the theoretical constraint derived by Woosley & Hoffman (1991). However, this constraint is obtained on the assumption that the explosion is spherically symmetric, whereas Cas A is famous for the asymmetric form of the remnant. Recently, Nagataki et al. (1997) calculated the explosive nucleosynthesis of axisymmetrically deformed collapse-driven supernova. They reported that the ratio of $^{44}Ti/^{56}Ni$ was enhanced by the stronger alpha-rich freezeout in the polar region. In this paper, we apply these results to Cas A and examine whether this effect can explain the large amount of $^{44}Ti$ and the large ratio of $^{44}Ti/^{56}Ni$. We demonstrate that the conventional spherically symmetric explosion model can not explain the $^{44}$Ti mass produced in Cas A if its lifetime is shorter than $\sim$ 80 years and the intervening space is transparent to the gamma-ray line from the decay of $^{44}$Ti. On the other hand, we show the axisymmetric explosion models can solve the problem. We expect the same effect from a three dimensionally asymmetric explosion, since the stronger alpha-rich freezeout will also occur in that case in the region where the larger energy is deposited.Comment: 10 pages, LaTeX text and 3 postscript figure

Toward a simulation approach for alkene ring-closing metathesis : scope and limitations of a model for RCM

A published model for revealing solvent effects on the ring-closing metathesis (RCM) reaction of di-Et diallylmalonate 7 has been evaluated over a wider range of conditions, to assess its suitability for new applications. Unfortunately, the model is too flexible and the published rate consts. do not agree with exptl. studies in the literature. However, by fixing the values of important rate consts. and restricting the concn. ranges studied, useful conclusions can be drawn about the relative rates of RCM of different substrates, precatalyst concn. can be simulated accurately and the effect of precatalyst loading can be anticipated. Progress has also been made toward applying the model to precatalyst evaluation, but further modifications to the model are necessary to achieve much broader aims

Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11

Variants in NDUFB11, which encodes a structural component of complex I of the mitochondrial respiratory chain (MRC), were recently independently reported to cause histiocytoid cardiomyopathy (histiocytoid CM) and microphthalmia with linear skin defects syndrome (MLS syndrome). Here we report an additional case of histiocytoid CM, which carries a de novo nonsense variant in NDUFB11 (ENST00000276062.8: c.262C > T; p.[Arg88*]) identified using whole-exome sequencing (WES) of a family trio. An identical variant has been previously reported in association with MLS syndrome. The case we describe here lacked the diagnostic features of MLS syndrome, but a detailed clinical comparison of the two cases revealed significant phenotypic overlap. Heterozygous variants in HCCS (which encodes an important mitochondrially targeted protein) and COX7B, which, like NDUFB11, encodes a protein of the MRC, have also previously been identified in MLS syndrome including a case with features of both MLS syndrome and histiocytoid CM. However, a systematic review of WES data from previously published histiocytoid CM cases, alongside four additional cases presented here for the first time, did not identify any variants in these genes. We conclude that NDUFB11 variants play a role in the pathogenesis of both histiocytoid CM and MLS and that these disorders are allelic (genetically related)

Thorium Energy Futures

The potential for thorium as an alternative or supplement to uranium in fission power generation has long been recognised, and several reactors, of various types, have already operated using thorium-based fuels. Accelerator Driven Subcritical (ADS) systems have benefits and drawbacks when compared to conventional critical thorium reactors, for both solid and molten salt fuels. None of the four options – liquid or solid, with or without an accelerator – can yet be rated as better or worse than the other three, given today's knowledge. We outline the research that will be necessary to lead to an informed choice

The Compact Central Object in Cas A: A Neutron Star with Hot Polar Caps or a Black Hole?

The central pointlike X-ray source of the Cas A supernova remnant was discovered in the Chandra First Light Observation and found later in the archival ROSAT and Einstein images. The analysis of these data does not show statistically significant variability of the source. The power-law fit yields the photon index 2.6-4.1, and luminosity (2-60)e34 erg/s, for d=3.4 kpc. The power-law index is higher, and the luminosity lower, than those observed fromvery young pulsars. One can fit the spectrum equally well with a blackbody model with T=6-8 MK, R=0.2-0.5 km, L=(1.4-1.9)e33 erg/s. The inferred radii are too small, and the temperatures too high, for the radiationcould be interpreted as emitted from the whole surface of a uniformly heated neutron star. Fits with the neutron star atmosphere models increase the radius and reduce the temperature, but these parameters are still substantially different from those expected for a young neutron star. One cannot exclude, however, that the observed emission originates from hot spots on a cooler neutron star surface. Because of strong interstellar absorption, the possible low-temperature component gives a small contribution to the observed spectrum; an upper limit on the (gravitationally redshifted) surface temperature is < 1.9-2.3 MK. Amongst several possible interpretations, we favor a model of a strongly magnetized neutron star with magnetically confined hydrogen or helium polar caps on a cooler iron surface. Alternatively, the observed radiation may be interpreted as emitted by a compact object (more likely, a black hole) accreting from a fossil disk or from a late-type dwarf in a close binary.Comment: 12 pages, 2 figures, submitted to ApJ

The perception and management of risk in UK office property development

Risk is an ever-present aspect of business, and risk taking is necessary for profit and economic progress. Speculative property development is popularly perceived as a 'risky business' yet, like other entrepreneurs, developers have opportunities to manage the risks they face; techniques include phasing and joint ventures. The associated areas of investment portfolio risk, development risk analysis and construction risk management have all been addressed by research. This article presents new knowledge about how developers perceive risks and the means they subsequently adopt to manage them. The developers of office projects across the UK were sent questionnaires by post. Respondents were asked about their perceptions of risks at the first appraisal stage and currently and about the risk management techniques that they had adopted. In-depth interviews with a selection of respondents were then used to discuss and augment the findings. Developers were most concerned about market-based risks at both stages. Concern about production-orientated risks was lower and fell significantly between the two stages. A fixed price contract was the most common risk management technique. Risk management techniques were used more often outside London and the South East. Developer type affects both the perception and management of risk. While developers do manage risk, decisions are made on the basis of professional and business experience. These findings should help development companies manage risk in a more objective and analytical way